Vancomycin · Restricted first-order model

Vancomycin Two-Level AUC

A transparent steady-state, one-compartment alternative when a validated Bayesian model is not being used—not a replacement for Bayesian software or local protocol.

Evidence recordRestricted clinical scopeVersion 0.1 · Updated July 17, 2026

Required model acknowledgement

Timing and model assumptions determine whether this result is usable.

This calculator requires two accurately timed post-distribution levels from the same steady-state interval, a stable dose and interval, and stable elimination. It is not valid for rapidly changing renal function, dialysis or other extracorporeal clearance, infusion overlap, undocumented doses, or samples taken during distribution.

This is first-order one-compartment estimation, not Bayesian forecasting.
The 400–600 AUC/MIC context applies to serious invasive MRSA infections with MIC assumed to be 1 mg/L; it is not a universal vancomycin target.
The calculator will not recommend a replacement dose or interval.

I have verified the administration and sample times, understand the steady-state one-compartment assumptions, and will use the applicable institutional protocol.

Vancomycin AUC Calculator – Two Levels

Use this two-level vancomycin AUC calculator only when its steady-state, timing, and one-compartment assumptions fit the clinical situation and a validated Bayesian model is not being used.

The tool requires two accurately timed post-distribution levels from the same steady-state interval. It keeps model restrictions visible and does not automatically recommend a replacement regimen.